GCS. It has a pronounced anti-inflammatory and anti-allergic effect, has anti-shock and immunosuppressive activity. It affects various types of metabolism: increases blood glucose, has a catabolic effect, promotes redistribution of adipose tissue, can cause osteoporosis, causes a delay in sodium and water ions in the body, and increases blood pressure. Affects the inflammatory process in the connective tissue and reduces the possibility of scar tissue formation.
Prednisone is an inactive substance, which, after absorption from the gastrointestinal tract, enters the liver and turns into the active metabolite prednisolone. The binding of prednisolone to plasma proteins is 90%. Prednisone further undergoes biotransformation in the liver, kidneys and bronchi to oxidized forms, which form conjugates with sulfuric and glucuronic acids. It is excreted by the kidneys mainly unchanged.
Peptic ulcer of the stomach and duodenum in the exacerbation phase, osteoporosis, Itsenko-Cushing's disease, tendency to thromboembolism, renal failure, severe arterial hypertension, systemic mycoses, viral infections, vaccination period, active tuberculosis, glaucoma, productive symptoms of mental illness. Hypersensitivity to prednisone.
Pregnancy and lactation
When pregnancy (especially in the first trimester) is used for health reasons.
From the endocrine system: Itsenko-Cushing's syndrome, weight gain, hyperglycemia until the development of steroid diabetes, depletion (up to atrophy) of the adrenal cortex, negative nitrogen balance.
From the digestive system: increased acidity of the gastric juice, ulcerogenic effect on the gastrointestinal tract.
From the water-electrolyte balance: increased excretion of potassium, sodium retention in the body with the formation of edema.
From the cardiovascular system: arterial hypertension.
From the musculoskeletal system: osteoporosis, aseptic necrosis of bones.
From the side of the central nervous system: mental disorders, steroid cataract, provoking latent glaucoma.
Other: reduced resistance to infections, delayed wound healing, increased blood coagulation.
Dosage and administration
Individual. For adults, the initial dose is 20-30 mg / day, the maintenance dose is 5-10 mg / day. If necessary, the initial dose may be 15-100 mg / day, the maintenance dose is 5-15 mg / day. The daily dose should be reduced gradually. For children, the initial dose is 1-2 mg / kg / day in 4-6 doses, the supporting dose is 300-600 mcg / kg / day.
During treatment (especially long), it is necessary to observe an ophthalmologist, monitor blood pressure and water-electrolyte balance, as well as pictures of peripheral blood and blood glucose levels; In order to reduce side effects, you can prescribe anabolic steroids, antibiotics, as well as increase the intake of potassium in the body (diet, potassium preparations).
With a history of psoriasis, high-dose prednisone is prescribed under the strict supervision of a physician. In diabetes mellitus, it is prescribed only with absolute indications or to prevent the alleged insulin resistance. For non-specific infections, it is used with caution and under the condition of simultaneous chemo- or antibiotic therapy. With latent forms of tuberculosis, prednisone can be used only in combination with anti-TB drugs.
In Addison's disease, simultaneous use with barbiturates should be avoided.
After discontinuation of treatment, withdrawal syndrome, adrenal insufficiency, as well as an exacerbation of the disease, for which prednisone was prescribed, may occur.